vendredi 20 juin 2014

Contrat unique pour les essais cliniques industriels

Contrat unique pour les essais cliniques industriels - Le Leem salue une avancée majeure en faveur de l’attractivité française de la recherche clinique

Les enquêtes menées par le Leem depuis 2002 pour évaluer la place de la France dans la recherche clinique internationale mettent en évidence l’érosion continue de la position de la France, en raison notamment de difficultés administratives liées à la signature, avec les établissements de santé, des contrats nécessaires à la mise en place des essais cliniques.

vendredi 13 juin 2014

A holistic approach for modeling the dynamic of chikungunya and developing control actions

Présentation du modèle de propagation du Chikungunya au Congrès ASAIHL à Montpellier le 12 juin 2014, pour lequel je suis co-auteur s'agissant de la partie clinique.

 A holistic approach for modeling the dynamic of chikungunya and developing control actions

Roger Frutos1,2,*, Aurélie Merlin3, Siobhan Staunton4, Patrice Ravel5, Mireille Fargette3, Hervé Quiquanpoix5, Tri Baskoro Tunggul Satoto6, Erna Andayani7, Susi Damayanti6, Guilhem Kister5, Yannick Bardie8, Emmanuel Cornillot1, Christian Devaux1, Catherine Moulia9, Laurent Gavotte9 Thérèse Libourel3, Laurence Briant1, Nathalie Chazal1

1: Centre d’étude des Pathogènes et Biotechnologies pour la Santé, CPBS, UMR 5236 CNRS - UM1- UM2, Montpellier, France
2: Intertryp, UMR 77 CIRAD-IRD, Montpellier, France
3: Espace Dev, UMR IRD-UM2-UAG-ULR, Montpellier, France
4: Eco&Sols, UMR 210, INRA-IRD-CIRAD-Supagro, Montpellier France
5: Laboratoire de physique industrielle et traitement de l’information, EA2415 UM1, Montpellier, France
6: Center for Tropical Medicine, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia
7: Sukoharjo Regency Health Center, Center of Java, Sukoharjo, Indonesia
8: Intelligence in Life – R&D Clinique SARL, Montpellier, France
9: Institut des Sciences de l’Evolution de Montpellier - ISEM, UMR 5557 CNRS – UM2, Montpellier, France
* Corresponding author:,

Objectives: We developed integrative approaches for the study of emerging diseases. Chikungunya virus (CHIKV), a mosquito-borne pathogen from the alphavirus genius transmitted by Aedes mosquitoes (Aedes aegypti and Aedes albopictus) causes acute infection in humans characterized by rash, high fever and, its hallmark feature is a severe arthritis that can persist for years. These disease was taken as a model system. Modeling the dynamic of the disease in Asia, where the CHIKV is actively propagating, is essential to develop prevention strategies for regions with high risk of propagation, including Europe where the vector A. albopictus is now well established. Multidisciplinary and multi-scale approaches are considered in our solutions.
Methods: We have constructed an object model (UML class diagram) to describe the structure of the system. This object model has been extended to dengue. The modeling of the dynamic of the transmission of CHIKV was performed with a multi-agent system implemented on the Netlogo platform. A case study has been selected in the region of Yogyakarta-Sukoharjo, Indonesia to validate both static and dynamic models. Information relative to geolocalisation, demography, environment (rural, urban, industrial, …), clinical information, vector population, has been collected on the field using standardized procedures.
Results: The class diagram defines the compartments of the model. We carefully describe compartments concerning environment description (description referring to geographic standards, ecology, anthropic influence), sample description (vector, human, virus triptych), clinical data (including media influence) and diagnostic tools. Data have been collected in a periurban zone of Yogyakarta (RT42) and a rural section of Sukoharjo district (RT02 and RT03). A questionnaire to collect clinical information has been set up following OBOE standard and presented to the local health centers. The index case was successfully established in the rural region. SEIR (Sensitive/Exposed/Infected/Resistant) compartments were considered for the host while SEI (Sensitive/Exposed/Infected) were selected for the vector to establish the dynamic model. We have been able to test the influence of medical care policies, vector control options and external income of virus. We also develop analyses on the fate and persitance of mosquitocidal agents post treatment.
Conclusion: We have tested the influence of medical practices in the development of the illness. Isolation of patients during the acute initial phase of the infection would avoid transmission and should drastically reduce the transmission of the virus. According to our study, the presence of large factories in the region of Sukoharjo is suspected to constitute the major source of CHIKV for the region. Whether factories provide suitable habitat for local populations of vector and whether industrial activity contributes to the introduction of populations originating elsewhere will be tested by further serological and molecular analyses.

mercredi 11 juin 2014

Intelligence in Life

Health experts in clinical research, we work on Information and Communications Tech innovations to improve and promote sustainable ethical clinical development.
Lien vers le Twitter:


The Association of Southeast Asian Institutions of Higher Learning (ASAIHL) was founded in 1956 as a non-governmental organization at a meeting in Bangkok of the heads of eight state universities in Southeast Asia. Field Marshal Pibulsongkram, the Prime Minister, supported its foundation and approved setting up the Secretariat in Thailand. His government began by giving financial and material support, which continued for several years until the Association had other sources of funds. More recently, in addition to physical facilities, the Thai government has been supporting the Association with a grant of US $5,000 annually.
ASAIHL’s purpose is to assist member institutions to strengthen themselves through mutual self help and to achieve international distinction in teaching, research and public service. In so doing, the institutions contribute strength to their respective nations and to the entire region.
Specifically, the Association exists to foster the development of the institutions themselves, the cultivation of a sense of regional identity and interdependence and liaison with other regional and international organizations concerned with research and teaching.
It serves as a clearing-house of information  provides regular opportunities for the discussion of academic development and general university development; assists member institutions in the recruitment and placement of faculty and staff, exchanges of professors and students and in the development of co-operative arrangements on specific projects; provides advisory services of consultants; strengthens the relationship with regional and international bodies and keeps member institutions informed about developments; und recognizes and acknowledges distinctive achievements among Southeast Asian institutions of higher education.

Founding Fathers :

- Sir Nicholas Attygalle, University of Ceylon
- Air Marshal Muni M. Vejyant Rangshrisht, Chulalongkorn University
- Dr. Lindsay Ride, University of Hong Kong
- Prof. Bahder Djohan, University of Indonesia
- Sir Sydney Caine, University of Malaya
- Dr. Vidal A. Tan, University of the Philippines
- Dr. Htin Aung, University of Rangoon
- Prof. Nguyen-Quang-Trinh, National University of Vietnam

Interview Radio AVIVA 

Mon interview sur Radio-Aviva au sujet de l'ouvrage "Essais Cliniques, du patient à l'objet de science".